Design and synthesis of new drugs with antioxidant, antiviral, antibiotic and anti-tumor activities, with special reference to beta-lactam derivatives, purines, pyrimidines, imidazoles, other heterocycles, phenolic and polyphenolic compounds. Development of new synthetic pathways alternatives to the processes covered by the patent literature. Optimization of specific stages in the synthesis of drugs via catalysis and bio-catalysis. Design and development of synthesis in alternative reaction solvents (ionic liquids, fluorinated solvents, phase-transfer catalysis, super critical carbon dioxide). Application of organometallic catalysis in the synthesis of biologically active substances.